Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Longitudinal evidence for diminished frontal-cortex function in aging
Umeå universitet, Umeå, Sweden.
Umeå universitet, Umeå, Sweden.
Umeå universitet, Umeå, Sweden.
Umeå universitet, Umeå, Sweden.
Show others and affiliations
2010 (English)In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 107, no 52, 22682-22686 p.Article in journal (Refereed) Published
Abstract [en]

Cross-sectional estimates of age-related changes in brain structure and function were compared with 6-y longitudinal estimates. The results indicated increased sensitivity of the longitudinal approach as well as qualitative differences. Critically, the cross-sectional analyses were suggestive of age-related frontal overrecruitment, whereas the longitudinal analyses revealed frontal underrecruitment with advancing age. The cross-sectional observation of overrecruitment reflected a select elderly sample. However, when followed over time, this sample showed reduced frontal recruitment. These findings dispute inferences of true age changes on the basis of age differences, hence challenging some contemporary models of neurocognitive aging, and demonstrate age-related decline in frontal brain volume as well as functional response.

Place, publisher, year, edition, pages
2010. Vol. 107, no 52, 22682-22686 p.
Keyword [en]
brain imaging, longitudinal method, cross-sectional method, Betula
National Category
Psychology Gerontology, specializing in Medical and Health Sciences
Research subject
Psychology
Identifiers
URN: urn:nbn:se:su:diva-52284DOI: 10.1073/pnas.1012651108ISI: 000285684200062PubMedID: 21156826Scopus ID: 2-s2.0-78651086556OAI: oai:DiVA.org:su-52284DiVA: diva2:386933
Note

We thank the staff of the BETULA Project, R. Adolfsson, and the staff at the Umeå Center for Functional Brain Imaging. This study was supported by the Göran Gustafsson Award in Medicine (to L.N.), a grant from the Swedish Science Council (to L.N.), and a Wallenberg Scholar Grant from the Knut and Alice Wallenberg Foundation (to L.N.). The BETULA Project is supported by a grant from the Swedish Science Council (to L.-G.N. and L.N.).

Available from: 2011-01-13 Created: 2011-01-13 Last updated: 2017-12-11Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedScopus

Search in DiVA

By author/editor
Persson, JonasNilsson, Lars-Göran
By organisation
Department of Psychology
In the same journal
Proceedings of the National Academy of Sciences of the United States of America
PsychologyGerontology, specializing in Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 29 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf