Longitudinal evidence for diminished frontal-cortex function in aging
2010 (English)In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 107, no 52, 22682-22686 p.Article in journal (Refereed) Published
Cross-sectional estimates of age-related changes in brain structure and function were compared with 6-y longitudinal estimates. The results indicated increased sensitivity of the longitudinal approach as well as qualitative differences. Critically, the cross-sectional analyses were suggestive of age-related frontal overrecruitment, whereas the longitudinal analyses revealed frontal underrecruitment with advancing age. The cross-sectional observation of overrecruitment reflected a select elderly sample. However, when followed over time, this sample showed reduced frontal recruitment. These findings dispute inferences of true age changes on the basis of age differences, hence challenging some contemporary models of neurocognitive aging, and demonstrate age-related decline in frontal brain volume as well as functional response.
Place, publisher, year, edition, pages
2010. Vol. 107, no 52, 22682-22686 p.
brain imaging, longitudinal method, cross-sectional method, Betula
Psychology Gerontology, specializing in Medical and Health Sciences
Research subject Psychology
IdentifiersURN: urn:nbn:se:su:diva-52284DOI: 10.1073/pnas.1012651108ISI: 000285684200062PubMedID: 21156826ScopusID: 2-s2.0-78651086556OAI: oai:DiVA.org:su-52284DiVA: diva2:386933
We thank the staff of the BETULA Project, R. Adolfsson, and the staff at the Umeå Center for Functional Brain Imaging. This study was supported by the Göran Gustafsson Award in Medicine (to L.N.), a grant from the Swedish Science Council (to L.N.), and a Wallenberg Scholar Grant from the Knut and Alice Wallenberg Foundation (to L.N.). The BETULA Project is supported by a grant from the Swedish Science Council (to L.-G.N. and L.N.).2011-01-132011-01-132015-09-01Bibliographically approved