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Chemically modified cell-penetrating peptides for the delivery of nucleic acids
Stockholm University, Faculty of Science, Department of Neurochemistry. Karolinska Institutet, Sweden; University of Tartu, Estonia.
Stockholm University, Faculty of Science, Department of Neurochemistry. University of Tartu, Estonia.
Stockholm University, Faculty of Science, Department of Neurochemistry. University of Tartu, Estonia.
Stockholm University, Faculty of Science, Department of Neurochemistry. University of Tartu, Estonia.ORCID iD: 0000-0001-6107-0844
2009 (English)In: Expert Opinion on Drug Delivery, ISSN 1742-5247, Vol. 6, no 11, 1195-1205 p.Article in journal (Refereed) Published
Abstract [en]

Short nucleic acids targeting biologically important RNAs and plasmids have been shown to be promising future therapeutics; however, their hydrophilic nature greatly limits their utility in clinics and therefore efficient delivery vectors are greatly needed. Cell-penetrating peptides (CPPs) are relatively short amphipathic and/or cationic peptides that are able to transport various biologically active molecules inside mammalian cells, both in vitro and in vivo, in a seemingly non-toxic fashion. Although CPPs have proved to be appealing drug delivery vehicles, their major limitation in nucleic acid delivery is that most of the internalized peptide-cargo is entrapped in endosomal compartments following endocytosis and the bioavailability is therefore severely reduced. Several groups are working towards overcoming this obstacle and this review highlights the evidence that by introducing chemical modification in CPPs, the bioavailability of delivered nucleic acids increases significantly.

Place, publisher, year, edition, pages
2009. Vol. 6, no 11, 1195-1205 p.
Keyword [en]
Cell-penetrating peptide, Gene delivery, Oligonucleotide delivery, Splice correction, Stearylation
National Category
Biological Sciences Chemical Sciences
Research subject
Neurochemistry with Molecular Neurobiology
Identifiers
URN: urn:nbn:se:su:diva-31296DOI: 10.1517/17425240903213688ISI: 000272476500005PubMedID: 19831582OAI: oai:DiVA.org:su-31296DiVA: diva2:387009
Available from: 2011-01-13 Created: 2009-11-09 Last updated: 2015-04-21Bibliographically approved

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