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Benchmarking nuclear models of FLUKA and GEANT4 for carbon ion therapy
Stockholm University, Faculty of Science, Medical Radiation Physics (together with KI).
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2010 (English)In: Physics in Medicine and Biology, ISSN 0031-9155, E-ISSN 1361-6560, Vol. 55, no 19, 5833-5847 p.Article in journal (Refereed) Published
Abstract [en]

As carbon ions, at therapeutic energies, penetrate tissue, they undergo inelastic nuclear reactions and give rise to significant yields of secondary fragment fluences. Therefore, an accurate prediction of these fluences resulting from the primary carbon interactions is necessary in the patient's body in order to precisely simulate the spatial dose distribution and the resulting biological effect. In this paper, the performance of nuclear fragmentation models of the Monte Carlo transport codes, FLUKA and GEANT4, in tissue-like media and for an energy regime relevant for therapeutic carbon ions is investigated. The ability of these Monte Carlo codes to reproduce experimental data of charge-changing cross sections and integral and differential yields of secondary charged fragments is evaluated. For the fragment yields, the main focus is on the consideration of experimental approximations and uncertainties such as the energy measurement by time-of-flight. For GEANT4, the hadronic models G4BinaryLightIonReaction and G4QMD are benchmarked together with some recently enhanced de-excitation models. For non-differential quantities, discrepancies of some tens of percent are found for both codes. For differential quantities, even larger deviations are found. Implications of these findings for the therapeutic use of carbon ions are discussed.

Place, publisher, year, edition, pages
2010. Vol. 55, no 19, 5833-5847 p.
National Category
Natural Sciences
URN: urn:nbn:se:su:diva-52233DOI: 10.1088/0031-9155/55/19/014ISI: 000282061800014OAI: diva2:387016

authorCount :7

Available from: 2011-01-13 Created: 2011-01-13 Last updated: 2012-10-12Bibliographically approved
In thesis
1. Monte Carlo particle transport codes for ion beam therapy treatment planning: Validation, development and applications
Open this publication in new window or tab >>Monte Carlo particle transport codes for ion beam therapy treatment planning: Validation, development and applications
2012 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

External radiotherapy with proton and ion beams needs accurate tools for the dosimetric characterization of treatment fields. Monte Carlo (MC) particle transport codes, such as FLUKA and GEANT4, can be a valuable method to increase accuracy of dose calculations and to support various aspects of ion beam therapy (IBT), such as treatment planning and monitoring. One of the prerequisites for such applications is however that the MC codes are able to model reliably and accurately the relevant physics processes. As a first focus of this thesis work, physics models of MC codes with importance for IBT are developed and validated with experimental data. As a result suitable models and code configurations for applications in IBT are established. The accuracy of FLUKA and GEANT4 in describing nuclear fragmentation processes and the production of secondary charged nuclear fragments is investigated for carbon ion therapy. As a complementary approach to evaluate the capability of FLUKA to describe the characteristics of mixed radiation fields created by ion beams, simulated microdosimetric quantities are compared with experimental data. The correct description of microdosimetric quantities is also important when they are used to predict values of relative biological effectiveness (RBE). Furthermore, two models describing Compton scattering and the acollinearity of two-quanta positron annihilation at rest in media were developed, validated and integrated in FLUKA. The detailed description of these processes is important for an accurate simulation of positron emission tomography (PET) and prompt-γ imaging. Both techniques are candidates to be used in clinical routine to monitor dose administration during cancer treatments with IBT. The second objective of this thesis is to contribute to the development of a MC-based treatment planning tool for protons and ions with atomic number Z ≤ 8 using FLUKA. In contrast to previous clinical FLUKA-based MC implementations for IBT which only re-calculate a given treatment plan, the developed prototype features inverse optimization of absorbed dose and RBE-weighted dose for single fields and simultaneous multiple-field optimization for realistic treatment conditions. In a study using this newly-developed tool, the robustness of IBT treatment fields to uncertainties in the prediction of RBE values is investigated, while comparing different optimization strategies.

Place, publisher, year, edition, pages
Stockholm: Department of Physics, Stockholm University, 2012. 86 p.
Monte Carlo, ion beam therapy, treatment planning, cancer therapy, microdosimetry
National Category
Physical Sciences
Research subject
Medical Radiation Physics
urn:nbn:se:su:diva-81111 (URN)978-91-7447-551-7 (ISBN)
Public defence
2012-11-29, föreläsningssalen, Radiumhemmet, Karolinska universitetssjukhuset, Solna, 09:00 (English)
EU, FP7, Seventh Framework Programme, PITN-GA-2008-215840-PARTNEREU, FP7, Seventh Framework Programme, ENVISION FP7 Grant Agreement N. 241851

At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 5: Submitted. Paper 6: Manuscript.

Available from: 2012-11-07 Created: 2012-10-10 Last updated: 2013-04-08Bibliographically approved

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Böhlen, Till TobiasGudowska, Irena
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