Long-term impacts of antibiotic exposure on the human intestinal microbiota
2010 (English)In: Microbiology, ISSN 1350-0872, E-ISSN 1465-2080, Vol. 156, 3216-3223 p.Article, review/survey (Refereed) Published
Although it is known that antibiotics have short-term impacts on the human microbiome, recent evidence demonstrates that the impacts of some antibiotics remain for extended periods of time. In addition, antibiotic-resistant strains can persist in the human host environment in the absence of selective pressure. Both molecular- and cultivation-based approaches have revealed ecological disturbances in the microbiota after antibiotic administration, in particular for specific members of the bacterial community that are susceptible or alternatively resistant to the antibiotic in question. A disturbing consequence of antibiotic treatment has been the long-term persistence of antibiotic resistance genes, for example in the human gut. These data warrant use of prudence in the administration of antibiotics that could aggravate the growing battle with emerging antibiotic-resistant pathogenic strains.
Place, publisher, year, edition, pages
2010. Vol. 156, 3216-3223 p.
16S RIBOSOMAL-RNA; GRADIENT GEL-ELECTROPHORESIS; HELICOBACTER-PYLORI; ESCHERICHIA-COLI; FECAL MICROBIOTA; RESISTANCE GENE; ANTIMICROBIAL RESISTANCE; COLONIC MICROBIOTA; BACTEROIDES SPP.; COMMENSAL FLORA
Microbiology in the medical area
Research subject Microbiology
IdentifiersURN: urn:nbn:se:su:diva-51244DOI: 10.1099/mic.0.040618-0ISI: 000284660400003OAI: oai:DiVA.org:su-51244DiVA: diva2:387583
authorCount :42011-01-142011-01-102011-01-14Bibliographically approved