Organocatalytic enantioselective aziridination of α-substituted α,β-unsaturated aldehydes: asymmetric synthesis ot terminal aziridines
2010 (English)In: Advanced Synthesis and Catalysis, ISSN 1615-4150, E-ISSN 1615-4169, Vol. 352, no 18, 3201-3207 p.Article in journal (Refereed) Published
The first example of a highly enantioselective organocatalytic aziridination of α-substituted α,β-unsaturated aldehydes is presented. The reaction is catalyzed by simple chiral amines and gives access to highly functional terminal azirdines containing an α-tertiary amine stereocenter in high yields and enantiomeric ratios (95.5:4.5–98:2).
Place, publisher, year, edition, pages
2010. Vol. 352, no 18, 3201-3207 p.
asymmetric catalysis, domino reactions, organocatalysis, α-substituted α, β-unsaturated aldehydes, terminal aziridines
Research subject Organic Chemistry
IdentifiersURN: urn:nbn:se:su:diva-52926DOI: 10.1002/adsc.201000650OAI: oai:DiVA.org:su-52926DiVA: diva2:389363
FunderSwedish Research Council