Change search
ReferencesLink to record
Permanent link

Direct link
The CorA family: Structure and function revisited
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
2007 (English)In: Cellular and Molecular Life Sciences (CMLS), ISSN 1420-682X, E-ISSN 1420-9071, Vol. 64, no 19-20, 2564-2574 p.Article, review/survey (Refereed) Published
Abstract [en]

The CorA family is a group of ion transporters that mediate transport of divalent metal ions across biological membranes. Metal ions are essential elements in most cellular processes and hence the concentrations of ions in cells and organelles must be kept at appropriate levels. Impairment of these systems is implied in a number of pathological conditions. CorA proteins are abundant among the prokaryotic organisms but homologues are present in both human and yeast. The activity of CorA proteins has generally been associated with the transport of magnesium ions but the members of the CorA family can also transport other ions such as cobalt and nickel. The structure of the CorA from Thermotoga maritima, which also was the first structure of a divalent cation transporter determined, has opened the possibilities for understanding the mechanisms behind the ion transport and also corrected a number of assumptions that have been made in the past.

Place, publisher, year, edition, pages
2007. Vol. 64, no 19-20, 2564-2574 p.
Keyword [en]
membrane proteins, divalent cation transporter, magnesium transport, prokaryotes, topology
National Category
Natural Sciences
URN: urn:nbn:se:su:diva-55741DOI: 10.1007/s00018-007-7174-zISI: 000250538200012OAI: diva2:406747
authorCount :2Available from: 2011-03-28 Created: 2011-03-28 Last updated: 2011-03-28Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Niegowski, Damian
By organisation
Department of Biochemistry and Biophysics
In the same journal
Cellular and Molecular Life Sciences (CMLS)
Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 22 hits
ReferencesLink to record
Permanent link

Direct link