Maintenance of redundant small RNA gene copies over evolutionarytimescales via a retrotransposition motor?
(English)Manuscript (preprint) (Other academic)
We analysed the stability of duplicated, essential RNAs on the backdrop of theirexpression profiles to test whether the data is compatible with functional redundancy ordiversification. Under the former model, the expectation is that copies are equallyexpressed across tissues and subject to high turn-over. The latter model, in contrast,predicts that sub- or neofunctionalization following duplication may lead to a range ofcomplementary expression profiles across tissues. By example of the spliceosomal RNAU1 and snoRNA U3, we find that only few loci are stable over the course of vertebrateevolution and that the majority of copies show little or no expression. We conclude thatthese findings are most compatible with the redundancy model. Interestingly, the deepestloci are associated with a testis-expressed gene, suggesting a possible driving forcebehind the ongoing proliferation that we observe.
ncRNA, evolution, comparative genomics, expression
Cell and Molecular Biology
Research subject Molecular Biology
IdentifiersURN: urn:nbn:se:su:diva-56819OAI: oai:DiVA.org:su-56819DiVA: diva2:413239