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Age- and serogroup-related differences in observed durations of nasopharyngeal carriage of penicillin-resistant pneumococci
Stockholm University, Faculty of Science, Department of Mathematics.
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2007 (English)In: Journal of Clinical Microbiology, ISSN 0095-1137, E-ISSN 1098-660X, Vol. 45, no 3, 948-952 p.Article in journal (Refereed) Published
Abstract [en]

Using data from an ongoing Swedish intervention project, the observed durations of nasopharyngeal carriage of penicillin-nonsusceptible Streptococcus pneumoniae (PNSP) (MIC of penicillin G of >= 0.5 mu g/ml) stratified by both pneumococcal serogroup and age of the carrier were compared. The means and 95% confidence intervals (CIs) were estimated by fitting a gamma distribution to the observed duration of carriage for each age and serogroup stratum. The mean observed duration of carriage for all cases was 37 days (95% CI, 35 to 38 days). Children below the age of 5 years carried PNSP for significantly longer periods (43 days; 95% CI, 41 to 45 days) compared with older individuals (25 days; 95% CI, 24 to 27 days). There were also differences within the group of cases below the age of 5 years, as the duration of carriage became significantly shorter for each increasing age step: < 1, 1 to 2, and 3 to 4 years. In addition, patients < 5 years of age carried serogroups 9 and 14 for significantly shorter periods than groups 6 and 23. Serogroup 9 was also carried for significantly shorter periods than group 19. For patients aged 5 years or older, no significant difference in carriage duration for different ages or serogroups could be noted. As young children have the longest duration of PNSP carriage, interventions aiming to reduce the prevalence in this group are of great importance. The results highlight the importance of taking both serogroup and age of the carriers into account when studying the dynamics of pneumococcal transmission in young children.

Place, publisher, year, edition, pages
2007. Vol. 45, no 3, 948-952 p.
Keyword [en]
acute otitis-media, streptococcus-pneumoniae, intervention project, natural development, protein-a, colonization, antibodies, children, infection, disease
National Category
Probability Theory and Statistics
Identifiers
URN: urn:nbn:se:su:diva-56601DOI: 10.1128/JCM.01913-06ISI: 000245071500038OAI: oai:DiVA.org:su-56601DiVA: diva2:414010
Note
authorCount :6Available from: 2011-05-02 Created: 2011-04-19 Last updated: 2011-05-02Bibliographically approved

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