Covalent anchoring of a racemization catalyst to CALB-beads: towards dual immobilization of DKR catalysts
2011 (English)In: Tetrahedron Letters, ISSN 0040-4039, E-ISSN 1873-3581, Vol. 52, no 14, 1601-1604 p.Article in journal (Refereed) Published
The preparation of a heterogeneous bifunctional catalytic system, combining the catalytic properties of an organometallic catalyst (racemization) with those of an enzyme (enantioselective acylation) is described. A novel ruthenium phosphonate inhibitor was synthesized and covalently anchored to a lipase immobilized on a solid support (CALB, Novozym® 435). The immobilized bifunctional catalytic system showed activity in both racemization of (S)-1-phenylethanol and selective acylation of 1-phenylethanol.
Place, publisher, year, edition, pages
2011. Vol. 52, no 14, 1601-1604 p.
Bifunctional catalytic system, Metalloenzyme, DKR, Lipases, Heterogeneous catalysis
IdentifiersURN: urn:nbn:se:su:diva-56949DOI: 10.1016/j.tetlet.2011.01.106ISI: 000288730900014OAI: oai:DiVA.org:su-56949DiVA: diva2:414088
FunderSwedish Research Council