Change search
ReferencesLink to record
Permanent link

Direct link
Plasmodium falciparum exposure in utero, maternal age and parity influence the innate activation of foetal antigen presenting cells
Stockholm University, Faculty of Science, The Wenner-Gren Institute .
Show others and affiliations
2009 (English)In: Malaria Journal, ISSN 1475-2875, Vol. 8, 251- p.Article in journal (Refereed) Published
Abstract [en]

Background: Malaria in pregnancy is associated with immunological abnormalities in the newborns, such as hampered T-helper 1 responses and increased T-regulatory responses, while the effect of maternal Plasmodium falciparum infection on foetal innate immunity is still controversial. Materials and methods: The immunophenotype and cytokine release by dendritic cells (DC) and monocytes were evaluated in cord blood from 59 Beninese women with or without malaria infection by using flow cytometry. Results: Accumulation of malaria pigment in placenta was associated with a partial maturation of cord blood myeloid and plasmacytoid DC, as reflected by an up-regulated expression of the major histocompatibility complex class II molecules, but not CD86 molecules. Cells of newborns of mothers with malaria pigment in their placenta also exhibited significantly increased cytokine responses upon TLR9 stimulation. In addition, maternal age and parity influenced the absolute numbers and activation status of cord blood antigen-presenting cells. Lastly, maternal age, but not parity, influenced TLR3, 4 and 9 responses in cord blood cells. Discussion: Our findings support the view that placental parasitization, as indicated by the presence of malaria pigment in placental leukocytes, is significantly associated with partial maturation of different DC subsets and also to slightly increased responses to TLR9 ligand in cord blood. Additionally, other factors, such as maternal age and parity should be taken into consideration when analysing foetal/neonatal innate immune responses. Conclusion: These data advocate a possible mechanism by which PAM may modulate foetal/neonatal innate immunity.

Place, publisher, year, edition, pages
2009. Vol. 8, 251- p.
Keyword [en]
plasmacytoid dendritic cells, cord blood, immune-responses, placental malaria, ifn-gamma, t-cells, infection, tolerance, pregnancy, subsets
URN: urn:nbn:se:su:diva-59409DOI: 10.1186/1475-2875-8-251ISI: 000272255200001OAI: diva2:427421
authorCount :10Available from: 2011-06-28 Created: 2011-06-27 Last updated: 2011-06-28Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Troye-Blomberg, Marita
By organisation
The Wenner-Gren Institute
In the same journal
Malaria Journal

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 78 hits
ReferencesLink to record
Permanent link

Direct link