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The effectiveness of choline citrate infusions monitored by lymphocyte transformation test (LTT) in multiple sclerosis. A new approach to the diagnosis and treatment of the disease
Stockholm University, Faculty of Science, The Wenner-Gren Institute , Immunology.
2009 (English)In: Neuro - endocrinology letters, ISSN 0172-780X, Vol. 30, no 3, 331-334 p.Article in journal (Refereed) Published
Abstract [en]

The efficacy of intravenous choline citrate infusions was investigated in 34 patients with multiple sclerosis (MS) by clinical evaluation and by monitoring of lymphocyte proliferation in vitro against fragments of myelin basic protein (MOG-35-55, MBP15-31, PLP 39-15) over a period of 12 weeks. Patients have been diagnosed with MS at least one year before entering the study and suffered from mild relapsing/remitting course to long-term chronic progressive disease. Twenty one patients exhibited positive lymphocyte proliferation to myelin fragments prior to treatment and were therefore selected for further studies. Choline citrate was administered with a dosage of 1200mg/ 2x week for a period of 3 months. This treatment resulted in a significant decrease of lymphocyte proliferation to neural fragments (MOG- 35-55, MBP15-31) in lymphocyte transformation test (LTT). There was no significant SI change of PLP Peptide (PLP 39-15) LTT found after treatment with choline citrate. During the 3 mo observation period, patients remained stable and no side-effects of the treatment were observed. In addition, some patients reported long-lasting improvement (less paresthesia and increase of muscle strength in lower extremities) which was demonstrated up to 3 years later. In one spectacular case a commercial pilot was able to return to duty again after treatment. This pilot was allowed back in to his position as a commercial flying cockpit member and is on duty for more than 4 yrs now.

Place, publisher, year, edition, pages
2009. Vol. 30, no 3, 331-334 p.
Keyword [en]
Multiple sclerosis, choline citrate, Lymphocyte transformation test (LTT), myelin basic protein
National Category
Immunology
Identifiers
URN: urn:nbn:se:su:diva-59394ISI: 000272199300007OAI: oai:DiVA.org:su-59394DiVA: diva2:427722
Note
authorCount :3Available from: 2011-06-28 Created: 2011-06-27 Last updated: 2017-12-11Bibliographically approved

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