Change search
ReferencesLink to record
Permanent link

Direct link
Human Exposure to Triclosan via Toothpaste does not change CYP3A4 Activity or Plasma Concentrations of Thyroid Hormones
Stockholm University, Faculty of Science, Department of Applied Environmental Science (ITM).
Show others and affiliations
2009 (English)In: Basic & Clinical Pharmacology & Toxicology, ISSN 1742-7835, E-ISSN 1742-7843, Vol. 105, no 5, 339-344 p.Article in journal (Refereed) Published
Abstract [en]

Triclosan is an antibacterial compound commonly used in cosmetics and personal care products for everyday use. As previously shown, triclosan is found in the plasma, urine and milk from large parts of different human populations. Recent studies have revealed that triclosan is able to activate the human pregnane X receptor in vitro and thus possibly affecting metabolism of drugs in humans via the induction of CYP3A4. Besides, triclosan has been shown to affect thyroid hormonal levels in rats in vivo. In the present study, we investigated if an everyday exposure to triclosan via triclosan-containing toothpaste for 14 days in 12 adult humans caused an increase in plasma 4 beta-hydroxycholesterol, indicative of CYP3A4 induction, and/or alterations in thyroid hormonal status. The plasma triclosan concentrations increased from 0.009-0.81 ng/g to 26-296 ng/g (ranges) upon exposure. Despite this, there were no significant changes in plasma levels of either plasma 4 beta-hydroxycholesterol or thyroid hormones during the exposure. This indicates that the normal use of triclosan-containing toothpaste is not likely to alter metabolism of drugs via CYP3A4 induction or cause adverse events because of thyroid disturbances in humans.

Place, publisher, year, edition, pages
2009. Vol. 105, no 5, 339-344 p.
Keyword [en]
pregnane-x-receptor, ionization mass-spectrometry, personal care products, 2, 4, 4-trichloro-2-hydroxydiphenyl ether, cytochrome-p450 enzymes, gene-expression, rat-liver, induction, 4-beta-hydroxycholesterol, serum
National Category
Natural Sciences
URN: urn:nbn:se:su:diva-59683DOI: 10.1111/j.1742-7843.2009.00455.xISI: 000270785900009OAI: diva2:430255
authorCount :5Available from: 2011-07-07 Created: 2011-07-05 Last updated: 2011-07-07Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text
By organisation
Department of Applied Environmental Science (ITM)
In the same journal
Basic & Clinical Pharmacology & Toxicology
Natural Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 21 hits
ReferencesLink to record
Permanent link

Direct link