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Modeling the response of a population of olfactory receptor neurons to an odorant
Stockholm University, Faculty of Science, Numerical Analysis and Computer Science (NADA). Royal Institute of Technology, Sweden.
2009 (English)In: Journal of Computational Neuroscience, ISSN 0929-5313, E-ISSN 1573-6873, Vol. 27, no 3, 337-355 p.Article in journal (Refereed) Published
Abstract [en]

We modeled the firing rate of populations of olfactory receptor neurons (ORNs) responding to an odorant at different concentrations. Two cases were considered: a population of ORNs that all express the same olfactory receptor (OR), and a population that expresses many different ORs. To take into account ORN variability, we replaced single parameter values in a biophysical ORN model with values drawn from statistical distributions, chosen to correspond to experimental data. For ORNs expressing the same OR, we found that the distributions of firing frequencies are Gaussian at all concentrations, with larger mean and standard deviation at higher concentrations. For a population expressing different ORs, the distribution of firing frequencies can be described as the superposition of a Gaussian distribution and a lognormal distribution. Distributions of maximum value and dynamic range of spiking frequencies in the simulated ORN population were similar to experimental results.

Place, publisher, year, edition, pages
2009. Vol. 27, no 3, 337-355 p.
Keyword [en]
Olfaction, Sensory coding, Olfactory receptor neuron, Neural population modeling
National Category
Computer and Information Science
URN: urn:nbn:se:su:diva-59675DOI: 10.1007/s10827-009-0147-5ISI: 000271105700003OAI: diva2:430338

authorCount :4

Available from: 2011-07-08 Created: 2011-07-05 Last updated: 2015-01-14Bibliographically approved

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Lansner, Anders
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