Serum total cholesterol, statins and cognition in non-demented elderly
2009 (English)In: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 30, no 6, 1006-1009 p.Article in journal (Refereed) Published
Background: The association between serum total cholesterol (TC), lipid-lowering drugs and cognition in the elderly is currently controversial. Objective: To investigate the relationship between TC, lipid-lowering drugs and cognitive functions in non-demented elderly. Design and Setting: Participants of the Cardiovascular risk factors, aging and dementia (CAIDE) study were derived from random, population-based samples previously studied in 1972, 1977, 1982 or 1987. Analyses are based on 1382 non-demented participants re-examined in 1998 after an average follow-up of 21 years. Results: High midlife TC was associated with poorer late-life episodic memory and category fluency. TC decreased in most individuals over time. A more pronounced decrease was related to poorer late-life episodic memory and psychomotor speed, but not if subjects used statins. Conclusions: The TC-cognition relationship seems bidirectional. High midlife TC is associated with poorer late-life cognition, but decreasing TC after midlife may reflect poorer cognitive status. Statins may be beneficial for cognition in non-demented elderly.
Place, publisher, year, edition, pages
2009. Vol. 30, no 6, 1006-1009 p.
Statins, Midlife cholesterol, Changes in cholesterol, Cognition
IdentifiersURN: urn:nbn:se:su:diva-60083DOI: 10.1016/j.neurobiolaging.2007.09.012ISI: 000266062300015OAI: oai:DiVA.org:su-60083DiVA: diva2:432920
authorCount :102011-08-082011-08-082011-08-08Bibliographically approved