Change search
ReferencesLink to record
Permanent link

Direct link
Theoretical study of the hydroxylation of phenols mediated by an end-on bound superoxo-copper(II) complex
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
Stockholm University, Faculty of Science, Department of Physics.
2009 (English)In: Journal of Biological Inorganic Chemistry, ISSN 0949-8257, E-ISSN 1432-1327, Vol. 14, no 2, 273-285 p.Article in journal (Refereed) Published
Abstract [en]

Peptidylglycine alpha-amidating monooxygenase and dopamine beta-monooxygenase are copper-containing proteins which catalyze essential hydroxylation reactions in biological systems. There are several possible mechanisms for the reductive O-2-activation at their mononuclear copper active site. Recently, Karlin and coworkers reported on the reactivity of a copper(II)-superoxo complex which is capable of inducing the hydroxylation of phenols with incorporated oxygen atoms derived from the Cu(II)-O-2(-) moiety. In the present work the reaction mechanism for the abovementioned superoxo complex with phenols is studied. The pathways found are analyzed with the aim of providing some insight into the nature of the chemical and biological copper-promoted oxidative processes with 1:1 Cu(I)/O-2-derived species.

Place, publisher, year, edition, pages
2009. Vol. 14, no 2, 273-285 p.
Keyword [en]
Copper enzymes, Mononuclear copper complexes, Hydroxylation of phenols, Density functional theory, B3LYP functional
National Category
Physical Sciences
URN: urn:nbn:se:su:diva-60244DOI: 10.1007/s00775-008-0447-7ISI: 000264102000012OAI: diva2:434160
authorCount :4Available from: 2011-08-12 Created: 2011-08-11 Last updated: 2011-08-12Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Siegbahn, Per E. M.
By organisation
Department of Biochemistry and BiophysicsDepartment of Physics
In the same journal
Journal of Biological Inorganic Chemistry
Physical Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 18 hits
ReferencesLink to record
Permanent link

Direct link