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What Is the Role of Apolipoprotein E for Cognitive Functioning Across the Lifespan?
Stockholm University, Faculty of Social Sciences, Department of Psychology.
Stockholm University, Faculty of Social Sciences, Department of Psychology.
2011 (English)In: Biological Psychiatry, ISSN 0006-3223, E-ISSN 1873-2402, Vol. 70, no 2, 109-110 p.Article in journal (Refereed) Published
Abstract [en]

This study investigated APOE genotype and lipid levels in relation to some cognitive variables in children. However, there are other relevant cognitive variables remaining for study, such as executive functions and long-term declarative memory (episodic and semantic memory), often studied in connection to APOE in older adults. Design is also crucial to understand how the APOE gene affects cognitive functions across the lifespan. Longitudinal studies  (such as ALSPAC) are important in this respect. Taylor et al. found no evidence that the negative effects on cognitive functioning of the APOE ε4 allele appear as early as in the age span 7–14 years. Most studies of APOE involve older people, and therefore, the current study by Taylor et al. (3) on children represents a piece of important information that adds to the total picture of the role of APOE during the lifespan. Further research is needed to understand why the effects of APOE ε4 change from childhood to older age.

Place, publisher, year, edition, pages
2011. Vol. 70, no 2, 109-110 p.
Keyword [en]
APOE, cognition, lifespan
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Research subject
URN: urn:nbn:se:su:diva-62210DOI: 10.1016/j.biopsych.2011.05.023ISI: 000292036600002OAI: diva2:440342
Kommentar till: IQ, Educational Attainment, Memory and Plasma Lipids: Associations with Apolipoprotein E Genotype in 5995 Children, Biological Psychiatry, Volume 70, Issue 2, 15 July 2011, Pages 152-158, Amy E. Taylor, Philip A.I. Guthrie, George Davey Smith, Jean Golding, Naveed Sattar, Aroon D. Hingorani, John E. Deanfield, Ian N.M. Day.Available from: 2011-09-12 Created: 2011-09-12 Last updated: 2012-02-03Bibliographically approved

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Sternäng, OlaWahlin, Åke
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