Ruthenium-catalyzed asymmetric transfer hydrogenation of ketones in ethanol
2011 (English)In: Tetrahedron Letters, ISSN 0040-4039, E-ISSN 1873-3581, Vol. 52, no 21, 2754-2758 p.Article in journal (Refereed) Published
A ruthenium catalyst formed in situ by combining [Ru(p-cymene)Cl2]2 and an amino acid hydroxy-amide was found to catalyze efficiently the asymmetric reduction of aryl alkyl ketones under transfer hydrogenation conditions using ethanol as the hydrogen donor. The secondary alcohol products were obtained in moderate to good yields and with good to excellent enantioselectivity (up to 97% ee).
Place, publisher, year, edition, pages
2011. Vol. 52, no 21, 2754-2758 p.
Asymmetric catalysis, amino acids, ruthenium, reduction
IdentifiersURN: urn:nbn:se:su:diva-62769DOI: 10.1016/j.tetlet.2011.03.098ISI: 000290602100036OAI: oai:DiVA.org:su-62769DiVA: diva2:444500
FunderSwedish Research CouncilKnut and Alice Wallenberg Foundation