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Axonal transport and motor neuron disease
Stockholm University, Faculty of Science, Department of Neurochemistry.ORCID iD: 0000-0002-8630-2127
2011 (English)In: Cytoskeleton of the Nervous System / [ed] Nixon, Ralph A., Aidong Yuan, New York: Springer-Verlag New York, 2011, 529-544 p.Chapter in book (Refereed)
Abstract [en]

Describes cytoskeleton in axonal development and pathology, microtubules and associated proteins, neurofilaments and interacting proteins, actin and its binding proteins, and glial fibrillary acidic protein 2. Focuses on functional significance of neuronal cytoskeleton in axonal transport 3. Encourages further development of unifying principles, stimulates new conceptual and technical approaches toward a better understanding of cytoskeleton functions in health and disease Without a cytoskeleton, a neuron or glial cell would be a shapeless jelly mass unable to function in the milieu of the brain. If we are to understand neuronal cells function in health and disease, we must determine how the cytoskeleton forms and contributes to neural physiology and pathobiology. Cytoskeleton of the Nervous System provides a comprehensive, authoritative and up-to-date account of what we now know and what we want to know in the near future--about the functioning of the cytoskeleton of neuronal cells at the molecular level. In lively accounts, which are unafraid to address controversy, Cytoskeleton of the Nervous System introduces readers to the most sophisticated concepts and latest discoveries: from overexpression systems to knock-out models for specific cytoskeletal proteins, from continuous transport assays in vivo to live-cell imaging in primary neurons, and from factors regulating cytoskeleton behavior to the dysregulation of these processes leading to neurological disease.

Place, publisher, year, edition, pages
New York: Springer-Verlag New York, 2011. 529-544 p.
Series
Advances in Neurobiology, ISSN 2190-5215 ; 3
Keyword [en]
Amyotrophic lateral sclerosis, Axonal transport, Dynein, Kinesin, Motor neuron, SOD1
National Category
Biochemistry and Molecular Biology
Research subject
Neurochemistry with Molecular Neurobiology
Identifiers
URN: urn:nbn:se:su:diva-62952DOI: 10.1007/978-1-4419-6787-9_22ISBN: 9781441967862 (print)OAI: oai:DiVA.org:su-62952DiVA: diva2:446035
Available from: 2011-10-05 Created: 2011-10-05 Last updated: 2015-03-16Bibliographically approved

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