Change search
ReferencesLink to record
Permanent link

Direct link
A regulatory role for macrophage class A scavenger receptors in TLR4-mediated LPS responses.
Karolinska Institutet.
Karolinska Institutet.
Karolinska Institutet.
Stockholm University, Faculty of Science, Department of Genetics, Microbiology and Toxicology.
Show others and affiliations
2010 (English)In: European Journal of Immunology, ISSN 0014-2980, E-ISSN 1521-4141, Vol. 40, no 5, 1451-60 p.Article in journal (Refereed) Published
Abstract [en]

Recognition of microbial components by TLR, key sensors of infection, leads to induction of inflammatory responses. We found that, in vivo, TLR4 engagement by LPS induces up-regulation of the class A scavenger receptors (SR) macrophage receptor with a collagenous structure (MARCO) and SR-A, which occurs, at least in the case of MARCO, via both MyD88-dependent and -independent pathways. When challenging mice with a low dose of LPS followed by a high dose, class A SR-deficient mice showed a higher survival rate than WT mice. This was paired with increased production of IL-10 and anti-LPS Ab, as well as increased activation status of marginal zone B cells. However, the receptors were not crucial for survival when challenging mice i.p. with Neisseria meningitidis or Listeria monocytogenes, but they were found to contribute to microbial capture and clearance. This indicates physiological significance for the up-regulation of class A SR during early stages of bacterial infection. Thus, we believe that we have revealed a mechanism where SR regulate the activation status of the immune system and are involved in balancing a proper immune response to infection. This regulation could also be important in maintaining tolerance since these receptors have been shown to be involved in regulation of self-reactivity.

Place, publisher, year, edition, pages
2010. Vol. 40, no 5, 1451-60 p.
Keyword [en]
Class A scavenger receptors, KO mice, LPS response, Spleen marginal zone B cells
National Category
URN: urn:nbn:se:su:diva-63674DOI: 10.1002/eji.200939891PubMedID: 20162551OAI: diva2:451670
Available from: 2011-10-26 Created: 2011-10-26 Last updated: 2011-11-18Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
Department of Genetics, Microbiology and Toxicology
In the same journal
European Journal of Immunology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 97 hits
ReferencesLink to record
Permanent link

Direct link