Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Nucleoside phosphoramidates and related compounds: development of synthetic methods based on H-phosphonate chemistry
Stockholm University.
1999 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

In this thesis, studies directed towards development of new synthetic methods for the preparation of nucleotide analogues of potential medical value as antisense, antigene or antiviral agents, are described.

Two methods for synthesis of N3'->P5' and P3'->N5' phosphoramidate analogues with the nitrogen atom in bridging position of the internucleotide linkage was developed. Both of them make use of the readily available H-phosphonate monoesters as starting materials and permit the introduction of multiple modifications at the phosphorus center. In conjunction with these, a simple and efficient method for the preparation of nucleoside H-phosphonothioates, as a starting material for various phosphate analogues was also developed. As part of theses studies, base-induced disproportionation of aryl H-phosphonates was investigated.

A new type of prodrugs for AZT, symmetrical phosphoramidates, have been synthesised as potential anti-retroviral agent.

Place, publisher, year, edition, pages
Stockholm: Stockholm University , 1999. , 46 p.
National Category
Organic Chemistry
Research subject
Organic Chemistry
Identifiers
URN: urn:nbn:se:su:diva-64050ISBN: 91-7153-932-8 (print)OAI: oai:DiVA.org:su-64050DiVA: diva2:454521
Public defence
1999-06-04, 10:00
Opponent
Note
Härtill 7 uppsatserAvailable from: 2011-11-07 Created: 2011-11-07 Last updated: 2011-11-07Bibliographically approved

Open Access in DiVA

No full text

By organisation
Stockholm University
Organic Chemistry

Search outside of DiVA

GoogleGoogle Scholar

isbn
urn-nbn

Altmetric score

isbn
urn-nbn
Total: 50 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf