Secondary absorbed dose distributions and radiation quality in light ion therapy
2011 (English)Doctoral thesis, comprehensive summary (Other academic)
Radiotherapy with light ions offers the possibility of achieving a dose distribution which is highly conformed to the target volume while sparing normal tissues. For ions heavier than protons, an additional advantage is the increased Relative Biological Effectiveness (RBE) as compared to conventional photon and electron beams. During light ion therapy, nuclear fragments are produced in nuclear inelastic collisions of the projectile and the atomic nuclei in the material. In a cascade of events, the nuclear fragments in turn produce secondaries during their transport. The organs of the patient are thus exposed to a complex secondary radiation field and secondary doses can be delivered to normal tissues both close to and relatively far from the treated volume. In this thesis, secondary doses were evaluated in anthropomorphic phantoms which were developed for simulations with the Monte Carlo code SHIELD-HIT. Simulations of lung tumor, prostate and brain tumor irradiation with 1H, 4He, 7Li, 12C and 16O ion beams in the energy range 80-400 MeV/u were performed with SHIELD-HIT. The simulated organ absorbed doses were in the range 10-6-10-1 mGy per treatment Gy. In general, the organ absorbed doses decreased with increasing distance from the target volume and increased with increasing atomic number of the primary ions.
The produced nuclear fragments also influences the radiation quality in the target volume and thus the biological effectiveness of the beam. The dose-mean lineal energy, <yD>, was studied in a 290 MeV/u 12C beam by simulating the energy distributions of both primary and secondary ions and weighting their relative dose fractions with the corresponding energy-dependent <yD> which were obtained by ion-track simulations with PITS99 coupled with the electron transport code KURBUC. <yD> were evaluated in the target volume for object diameters 10-100 nm and were used in estimations of clinically useful weighting factors.
Place, publisher, year, edition, pages
Stockholm: Department of Physics, Stockholm University , 2011. , 54 p.
secondary doses, light ion therapy, radiation quality, Monte Carlo simulation
Research subject Medical Radiation Physics
IdentifiersURN: urn:nbn:se:su:diva-64302ISBN: 978-91-7447-412-1OAI: oai:DiVA.org:su-64302DiVA: diva2:456909
2011-12-20, Föreläsningssalen, Cancercentrum Karolinska, R8:00, Karolinska universitetssjukhuset, Solna, 13:00 (English)
Sato, Tatsuhiko, Dr
Gudowska, Irena, Docent
At the time of the doctoral defense, the following paper was unpublished and had a status as follows: Paper 4: Submitted.2011-11-282011-11-162016-01-18Bibliographically approved
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