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The CHH-superfamily of multifunctional peptide hormones controlling crustacean metabolism, osmoregulation, moulting, and reproduction
School of Biol. Sciences, Bangor University North Wales UK.
Institute for Molecular Biomedicine, University of Bonn, Germany.
Stockholm University, Faculty of Science, Department of Zoology, Functional Morphology. (Heinrich Dircksen)ORCID iD: 0000-0001-7815-4868
2012 (English)In: General and Comparative Endocrinology, ISSN 0016-6480, E-ISSN 1095-6840, Vol. 175, no 2, 217-233 p.Article in journal (Refereed) Published
Abstract [en]

Apart from providing an up-to-date review of the literature, considerable emphasis was placed in this article on the historical development of the field of “crustacean eyestalk hormones”. A role of the neurosecretory eyestalk structures of crustaceans in endocrine regulation was recognized about 80 years ago, but it took another half a century until the first peptide hormones were identified. Following the identification of crustacean hyperglycaemic hormone (CHH) and moult-inhibiting hormone (MIH), a large number of homologous peptides have been identified to this date. They comprise a family of multifunctional peptides which can be divided, according to sequences and precursor structure, into two subfamilies, type-I and -II. Recent results on peptide sequences, structure of genes and precursors are described here. The best studied biological activities include metabolic control, moulting, gonad maturation, ionic and osmotic regulation and methyl farnesoate synthesis in mandibular glands. Accordingly, the names CHH, MIH, and GIH/VIH (gonad/vitellogenesis-inhibiting hormone), MOIH (mandibular organ-inhibiting hormone) were coined. The identification of ITP (ion transport peptide) in insects showed, for the first time, that CHH-family peptides are not restricted to crustaceans, and data mining has recently inferred their occurrence in other ecdysozoan clades as well. The long-held tenet of exclusive association with the eyestalk X-organ-sinus gland tract has been challenged by the finding of several extra nervous system sites of expression of CHH-family peptides. Concerning mode of action and the question of target tissues, second messenger mechanisms are discussed, as well as binding sites and receptors. Future challenges are highlighted.

Place, publisher, year, edition, pages
Elsevier Inc. , 2012. Vol. 175, no 2, 217-233 p.
Keyword [en]
crustacean hyperglycaemic hormone, ion transport peptide, moult-inhibiting hormone, vitellogenesis-inhibiting hormone, X-organ-sinus gland system, Y-organ
National Category
Natural Sciences
Research subject
Zoological physiology
URN: urn:nbn:se:su:diva-65085DOI: 10.1016/j.ygcen.2011.11.035ISI: 000299137900001OAI: diva2:460860
Carl Tryggers Stiftelse
Available from: 2011-12-01 Created: 2011-12-01 Last updated: 2014-10-13Bibliographically approved

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