Highly enantioselective co-catalytic direct aldol reactions by combination of hydrogen-bond donating and acyclic amino acid catalysts
2011 (English)In: Advanced Synthesis and Catalysis, ISSN 1615-4150, E-ISSN 1615-4169, Vol. 353, no 17, 3114-3122 p.Article in journal (Refereed) Published
Highly enantioselective co-catalytic direct aldol reactions by a combination of simple hydrophobic acyclic amino acid and hydrogen-bond donating catalysts are presented. The corresponding aldol products are formed in high yields with high regio-, diastereo- (anti or syn) and enantioselectivity (up to 99.5:0.5 er). The catalyst loadings can be decreased to as little as 2 mol%.
Place, publisher, year, edition, pages
Wiley-VCH Verlagsgesellschaft, 2011. Vol. 353, no 17, 3114-3122 p.
aldol reaction, amino acids, asymmetric catalysis, co-catalysis, hydrogen-bond donating
IdentifiersURN: urn:nbn:se:su:diva-65524DOI: 10.1002/adsc.201100408ISI: 000298171500007OAI: oai:DiVA.org:su-65524DiVA: diva2:464020
FunderSwedish Research Council