Recruited vs. nonrecruited molecular signatures of brown, “brite,” and white adipose tissues
2011 (English)In: American Journal of Physiology. Endocrinology and Metabolism, ISSN 0193-1849, E-ISSN 1522-1555, Vol. 302, no 1, E19-E31 p.Article in journal (Refereed) Published
Mainly from cell culture studies, a series of genes have been identified that have been suggested to be characteristic of different types of adipocytes. Here we have examined gene expression patterns in nine defined adipose depots: interscapular BAT, cervical BAT, axillary BAT, mediastinic BAT, cardiac WAT, inguinal WAT, retroperitoneal WAT, mesenteric WAT and epididymal WAT. We found that each depot displayed a distinct gene expression fingerprint, but that three major types of depots were identifiable: the brown, the brite and the white. Although differences in gene expression pattern were generally quantitative, some gene markers showed, even in-vivo, remarkable depot specificities: Zic1 for the classical brown adipose tissue depots, Hoxc9 for the brite depots, Hoxc8 for the brite and white in contrast to the brown, and Tcf21 for the white depots. The significance of these gene expression patterns both for understanding the developmental background of the depots and as possible master regulators is discussed.
Place, publisher, year, edition, pages
2011. Vol. 302, no 1, E19-E31 p.
uncoupling protein 1, pr domain containing 16, sirtuins, short stature homeobox, carbonic anhydrase 3
IdentifiersURN: urn:nbn:se:su:diva-65632DOI: 10.1152/ajpendo.00249.2011ISI: 000298377600003PubMedID: 21828341OAI: oai:DiVA.org:su-65632DiVA: diva2:464306