Many research efforts have focused on the synthesis of organic and inorganic hybrid ordered mesoporous silicas (MSs) with functionalization of the exterior and/or interior surfaces aiming for applications in separation, adsorption, catalysis, drug delivery, and nanotechnology. Among the organic groups, the carboxylic group is a particularly useful reactive group for many applications. This article provides a brief overview of the carboxylic group functionalized MSs and the recent progress in synthetic strategies and applications have been reviewed.