Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Preserved Hippocampus Activation in Normal Aging as Revealed by fMRI
Stockholm University, Faculty of Social Sciences, Department of Psychology.
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI).
Stockholm University, Faculty of Social Sciences, Department of Psychology.
Show others and affiliations
2011 (English)In: Hippocampus, ISSN 1050-9631, E-ISSN 1098-1063, Vol. 21, no 7, 753-766 p.Article in journal (Refereed) Published
Abstract [en]

The hippocampus is deteriorated in various pathologies such as Alzheimer's disease (AD) and such deterioration has been linked to memory impairment. By contrast, the structural and functional effects of normal aging on the hippocampus is a matter of debate, with some findings suggesting deterioration and others providing evidence of preservation. This constitutes a crucial question since many investigations on AD are based on the assumption that the deterioration of the hippocampus is the breaking point between normal and pathological aging. A growing number of fMRI studies specifically aimed at investigating hippocampal engagement in various cognitive tasks, notably memory tasks, but the results have been inconclusive. Here, we optimized the episodic face-name paired-associates task in order to test the functioning of the hippocampus in normal aging. Critically, we found no difference in the activation of the hippocampus between the young and a group of older participants. Analysis of individual patterns of activation substantiated this impression. Collectively, these findings provide evidence of preserved hippocampal functioning in normal aging.

Place, publisher, year, edition, pages
2011. Vol. 21, no 7, 753-766 p.
Keyword [en]
aging, episodic memory, functional MRI, Hippocampus
National Category
Psychology Radiology, Nuclear Medicine and Medical Imaging Gerontology, specializing in Medical and Health Sciences
Research subject
Psychology
Identifiers
URN: urn:nbn:se:su:diva-66996DOI: 10.1002/hipo.20794ISI: 000292550500008OAI: oai:DiVA.org:su-66996DiVA: diva2:470036
Note

authorCount :5

Available from: 2011-12-28 Created: 2011-12-22 Last updated: 2017-12-08Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Persson, JonasNilsson, Lars-Göran
By organisation
Department of PsychologyAging Research Center (ARC), (together with KI)
In the same journal
Hippocampus
PsychologyRadiology, Nuclear Medicine and Medical ImagingGerontology, specializing in Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 22 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf