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CoMet-a web server for comparative functional profiling of metagenomes
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
2011 (English)In: Nucleic Acids Research, ISSN 0305-1048, E-ISSN 1362-4962, Vol. 39, w518-W523 p.Article in journal (Refereed) Published
Abstract [en]

Analyzing the functional potential of newly sequenced genomes and metagenomes has become a common task in biomedical and biological research. With the advent of high-throughput sequencing technologies comparative metagenomics opens the way to elucidate the genetically determined similarities and differences of complex microbial communities. We developed the web server 'CoMet' (http://comet.gobics.de), which provides an easy-to-use comparative metagenomics platform that is well-suitable for the analysis of large collections of metagenomic short read data. CoMet combines the ORF finding and subsequent assignment of protein sequences to Pfam domain families with a comparative statistical analysis. Besides comprehensive tabular data files, the CoMet server also provides visually interpretable output in terms of hierarchical clustering and multi-dimensional scaling plots and thus allows a quick overview of a given set of metagenomic samples.

Place, publisher, year, edition, pages
2011. Vol. 39, w518-W523 p.
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Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-66990DOI: 10.1093/nar/gkr388ISI: 000292325300084OAI: oai:DiVA.org:su-66990DiVA: diva2:470053
Note
authorCount :4Available from: 2011-12-28 Created: 2011-12-22 Last updated: 2017-12-08Bibliographically approved

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