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CoMet-a web server for comparative functional profiling of metagenomes
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
2011 (English)In: Nucleic Acids Research, ISSN 0305-1048, E-ISSN 1362-4962, Vol. 39, w518-W523 p.Article in journal (Refereed) Published
Abstract [en]

Analyzing the functional potential of newly sequenced genomes and metagenomes has become a common task in biomedical and biological research. With the advent of high-throughput sequencing technologies comparative metagenomics opens the way to elucidate the genetically determined similarities and differences of complex microbial communities. We developed the web server 'CoMet' (, which provides an easy-to-use comparative metagenomics platform that is well-suitable for the analysis of large collections of metagenomic short read data. CoMet combines the ORF finding and subsequent assignment of protein sequences to Pfam domain families with a comparative statistical analysis. Besides comprehensive tabular data files, the CoMet server also provides visually interpretable output in terms of hierarchical clustering and multi-dimensional scaling plots and thus allows a quick overview of a given set of metagenomic samples.

Place, publisher, year, edition, pages
2011. Vol. 39, w518-W523 p.
National Category
Biological Sciences
URN: urn:nbn:se:su:diva-66990DOI: 10.1093/nar/gkr388ISI: 000292325300084OAI: diva2:470053
authorCount :4Available from: 2011-12-28 Created: 2011-12-22 Last updated: 2011-12-28Bibliographically approved

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Schreiber, Fabian
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