Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Photochemical transformation of the thyroid hormone levothyroxine in aqueous solution
Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK), Environmental Chemistry.
2011 (English)In: Environmental science and pollution research international, ISSN 0944-1344, E-ISSN 1614-7499, Vol. 18, no 6, 871-876 p.Article in journal (Refereed) Published
Abstract [en]

Purpose The direct aqueous photolysis of the thyroid hormone levothyroxine (T(4)) has been studied. Methods and Result One of the major photoproducts, i.e., 4-[4-(2-amino-2-carboxy-ethyl)-2,6-diiodo-phenoxy]-penta-2,4-dienoic acid (P1), was isolated by liquid chromatography and structurally assigned by mass spectrometric (MS) and nuclear magnetic resonance spectroscopic methods. The identity of a second major product, i.e., 3,5-diiodo-l-thyrosine (P3), was confirmed through access to a commercially available standard. Furthermore, the structures of three additional transformation products are proposed on the basis of data obtained by high-resolution MS analyses. UV absorption spectra were determined for T(4) and the two photoproducts P1 and P3. Disappearance quantum yields were calculated for T(4) (I center dot = 0.014 at pH 12) and P3 (I center dot = 0.024 at pH 12 and I center dot = 0.010 at pH 8.5), whereas the compound P1 was found to be stable under the studied conditions (T(1/2) = 600 min). Conclusion The results indicate that solar UV light may have a significant impact on the fate of T(4) in the aquatic environment.

Place, publisher, year, edition, pages
2011. Vol. 18, no 6, 871-876 p.
Keyword [en]
Thyroid hormone, Photolysis, Photoproducts, Environmental fate
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:su:diva-66984DOI: 10.1007/s11356-011-0450-3ISI: 000292552400005OAI: oai:DiVA.org:su-66984DiVA: diva2:470067
Note
authorCount :3Available from: 2011-12-28 Created: 2011-12-22 Last updated: 2017-12-08Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Eriksson, Johan
By organisation
Environmental Chemistry
In the same journal
Environmental science and pollution research international
Chemical Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 18 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf