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Comparison of the helical tomotherapy against the multileaf collimator-based intensity-modulated radiotherapy and 3D conformal radiation modalities in lung cancer radiotherapy
Stockholm University, Faculty of Science, Department of Physics.
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2011 (English)In: British Journal of Radiology, ISSN 0007-1285, E-ISSN 1748-880X, Vol. 84, no 998, p. 161-172Article in journal (Refereed) Published
Abstract [en]

Objectives: The aim of this study was to compare three-dimensional (3D) conformal radiotherapy and the two different forms of IMRT in lung cancer radiotherapy. Methods: Cases of four lung cancer patients were investigated by developing a 3D conformal treatment plan, a linac MLC-based step-and-shoot IMRT plan and an HT plan for each case. With the use of the complication-free tumour control probability (P(+)) index and the uniform dose concept as the common prescription point of the plans, the different treatment plans were compared based on radiobiological measures. Results: The applied plan evaluation method shows the MLC-based IMRT and the HT treatment plans are almost equivalent over the clinically useful dose prescription range; however, the 3D conformal plan inferior. At the optimal dose levels, the 3D conformal treatment plans give an average P(+) of 48.1% for a effective uniform dose to the internal target volume (ITV) of 62.4 Gy, whereas the corresponding MLC-based IMRT treatment plans are more effective by an average Delta P(+) of 27.0% for a D effective uniform dose of 16.3 Gy. Similarly, the HT treatment plans are more effective than the 3D-conformal plans by an average Delta P(+) of 23.8% for a Delta effective uniform dose of 11.6 Gy. Conclusion: A radiobiological treatment plan evaluation can provide a closer association of the delivered treatment with the clinical outcome by taking into account the dose-response relations of the irradiated tumours and normal tissues. The use of P - effective uniform dose diagrams can complement the traditional tools of evaluation to compare and effectively evaluate different treatment plans.

Place, publisher, year, edition, pages
2011. Vol. 84, no 998, p. 161-172
Keyword [en]
Radiology, Nuclear Medicine, Medical Imaging
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Radiology, Nuclear Medicine and Medical Imaging
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URN: urn:nbn:se:su:diva-67364DOI: 10.1259/bjr/89275085ISI: 000286461700014OAI: oai:DiVA.org:su-67364DiVA, id: diva2:470137
Note
authorCount :8Available from: 2011-12-28 Created: 2011-12-28 Last updated: 2017-12-08Bibliographically approved

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