Change search
ReferencesLink to record
Permanent link

Direct link
The molecular basis for induction of human cancers by tobacco specific nitrosamines
Stockholm University, Faculty of Science, Department of Genetics, Microbiology and Toxicology.
2011 (English)In: Regulatory toxicology and pharmacology, ISSN 0273-2300, E-ISSN 1096-0295, Vol. 60, no 2, 268-280 p.Article in journal (Refereed) Published
Abstract [en]

Cellular DNA damage that is misrepaired or not repaired, constitutes a necessary, although not sufficient prerequisite for induction of cancer. For carcinogenic oral snuffs with extremely high concentrations of tobacco specific nitrosamines (TSNA) the DNA adduct levels predicted from animal experiments exceed those found in unexposed individuals. On the other hand, and supported by extensive Swedish epidemiological data, no significant increase of TSNA-induced DNA damages can be anticipated in humans from the use of low-nitrosamine oral snuffs. The extrapolated adduct concentrations are orders of magnitude lower than those found in the corresponding human tissues, a discrepancy that is difficult to account for by species differences. Furthermore, in exposed subjects the observed increment in the background levels of pyridyloxobutyl(POB)-hemoglobin adducts - a relevant indicator for TSNA activation - lie in a range predicted by rodent data. When based on the same type of tissues this provides justification for extrapolating rates of TSNA induced adduct formation from animals to humans. A TSNA exposure that does not affect the background level of pro-mutagenic DNA lesions should be considered as virtually safe. The high background concentrations of methylated and POB-DNA adducts in unexposed humans must be ascribed to other sources than tobacco.

Place, publisher, year, edition, pages
2011. Vol. 60, no 2, 268-280 p.
Keyword [en]
Nitrosamines, TSNA, Tobacco, Snuff, DNA adducts, Cancer, Risk assessment
National Category
Biological Sciences
URN: urn:nbn:se:su:diva-66966DOI: 10.1016/j.yrtph.2011.02.014ISI: 000292173100012OAI: diva2:470239
authorCount :1Available from: 2011-12-28 Created: 2011-12-22 Last updated: 2011-12-28Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Nilsson, Robert
By organisation
Department of Genetics, Microbiology and Toxicology
In the same journal
Regulatory toxicology and pharmacology
Biological Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 80 hits
ReferencesLink to record
Permanent link

Direct link