Change search
ReferencesLink to record
Permanent link

Direct link
Shift work at young age is associated with increased risk for multiple sclerosis
Stockholm University, Faculty of Social Sciences, Stress Research Institute. (Enheten för biologisk psykologi och behandlingsforskning)
Show others and affiliations
2011 (English)In: Annals of Neurology, ISSN 0364-5134, E-ISSN 1531-8249, Vol. 70, no 5, 733-41 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: Environmental factors play a prominent role in multiple sclerosis (MS) etiology. The aim of this study was to investigate the potential association between shift work and MS risk, which has previously never been investigated.

METHODS: This report is based on 2 population-based, case-control studies, 1 with incident cases (1,343 cases, 2,900 controls) and 1 with prevalent cases (5,129 cases, 4,509 controls). Using logistic regression, the occurrence of MS among subjects who have been exposed to shift work at various ages was compared with that of those who have never been exposed by calculating the odds ratio (OR) with a 95% confidence interval (CI).

RESULTS: In both studies, there was a significant association between working shift at a young age and occurrence of MS (OR, 1.6; 95% CI, 1.2-2.1 in the incidence study and OR, 1.3; 95% CI, 1.0-1.6 in the prevalence study). In the incident study, the OR of developing MS was 2.0 (95% CI, 1.2-3.6) among those who had worked shifts for 3 years or longer before age 20 years, compared with those who had never worked shifts. The OR for the corresponding comparison in the prevalent study was 2.1 (95% CI, 1.3-3.4).

INTERPRETATION: The observed association between shift work at a young age and occurrence of MS in 2 independent studies strengthens the notion of a true relationship. Consequences of shift work such as circadian disruption and sleep restriction are associated with disturbed melatonin secretion and enhanced proinflammatory responses and may thus be part of the mechanism behind the association.

Place, publisher, year, edition, pages
2011. Vol. 70, no 5, 733-41 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:su:diva-67596DOI: 10.1002/ana.22597ISI: 000297741600010PubMedID: 22006815Local ID: P2891OAI: diva2:470533
Available from: 2011-12-29 Created: 2011-12-29 Last updated: 2012-01-23Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Åkerstedt, Torbjörn
By organisation
Stress Research Institute
In the same journal
Annals of Neurology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 24 hits
ReferencesLink to record
Permanent link

Direct link