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Poor self-rated health is not associated with a high total allostatic load in type 2 diabetic patients--but high blood pressure is
Stockholm University, Faculty of Social Sciences, Stress Research Institute. (Enheten för psykoneuroimmunologi)
2011 (English)In: Diabetes & Metabolism, ISSN 1262-3636, Vol. 37, no 5, 446-51 p.Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: Allostatic load has been linked to self-rated health (SRH), cardiovascular disease and mortality in non-diabetic individuals. The aim of this study was to construct an allostatic load score and to find any correlations with SRH.

METHODS: The subjects included in the study came from a randomized, controlled trial of type 2 diabetes. Blood samples were drawn, urine was collected for 24h, and questionnaires, including SRH, were filled out on three occasions: at baseline; after the 10-week intervention; and at a follow-up 3 months after the intervention. Allostatic load was estimated using a wide range of variables, including systolic and diastolic blood pressure, pulse pressure, cortisol, catecholamines, HbA(1c), insulin, plasma glucose and waist circumference.

RESULTS: There was no association between SRH and allostatic load. However, three other components were significantly correlated with allostatic load at the baseline investigation and the two follow-up investigations - namely, systolic blood pressure, diastolic blood pressure and HbA(1c).

CONCLUSION: The absence of an association between allostatic load and SRH in diabetic individuals contrasts with previous findings in non-diabetic women, and shows that it is hazardous to apply findings in one population to another, especially diabetic and non-diabetic populations.

Place, publisher, year, edition, pages
2011. Vol. 37, no 5, 446-51 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:su:diva-67600DOI: 10.1016/j.diabet.2011.03.005ISI: 000297956400012PubMedID: 21596605Local ID: P2894OAI: diva2:470562
Available from: 2011-12-29 Created: 2011-12-29 Last updated: 2012-01-29Bibliographically approved

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