An Efficient Dynamic Kinetic Resolution of N-Heterocyclic 1,2-Amino Alcohols
2011 (English)In: Advanced Synthesis and Catalysis, ISSN 1615-4150, E-ISSN 1615-4169, Vol. 353, no 13, 2321-2327 p.Article in journal (Refereed) Published
A chemoenzymatic dynamic kinetic resolution (DKR) of N-heterocyclic amino alcohols is described. Various lipases were studied as biocatalysts for the kinetic resolution of N-heterocyclic 1,2-amino alcohols. The influence of the support of the enzymes on the enantioselectivity in the resolution of different substrates is highlighted. Various 3-acetoxypyrrolidines and -piperidines were obtained in high yield and high enantiomeric excess in efficient DKR reactions.
Place, publisher, year, edition, pages
2011. Vol. 353, no 13, 2321-2327 p.
amino alcohols, biocatalysis, dynamic kinetic resolution, enzymatic catalysis, lipase
IdentifiersURN: urn:nbn:se:su:diva-67265DOI: 10.1002/adsc.201100466ISI: 000295230900008OAI: oai:DiVA.org:su-67265DiVA: diva2:470961
authorCount :32011-12-302011-12-272014-10-23Bibliographically approved