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Scientific Opinion on Tetrabromobisphenol A (TBBPA) and its derivatives in food: EFSA Panel on Contaminants in the Food Chain (CONTAM)
Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK), Environmental Chemistry.
2011 (English)In: EFSA Journal, ISSN 1831-4732, Vol. 9, no 12, 2477- p.Article in journal (Refereed) Published
Abstract [en]

EFSA was asked by the European Commission to deliver a scientific opinion on tetrabromobisphenol A (TBBPA) and its derivatives in food. TBBPA and its derivatives are widely used as flame retardants. TBBPA is primarily used as reactive flame retardant covalently bound to epoxy and polycarbonate resins. TBBPA derivatives are used as either reactive or additive intermediates in polymer manufacture. Data from the analysis of TBBPA in 344 food samples were submitted to EFSA by two European countries (Norway and Spain), covering the period from 2007 to 2010. All samples were in the food group “Fish and other seafood”, and all analytical results were reported as less than the limit of quantification (LOQ) (about 1 ng/g wet weight). Toxicological studies with TBBPA have been carried out using different experimental designs with single or repeated administration during gestation, postnatally or in adulthood. The main target is thyroid hormone homeostasis. TBBPA is not genotoxic. There are no indications that TBBPA might be carcinogenic. The Panel on Contaminants in the Food Chain (CONTAM Panel) identified a lower confidence limit for a benchmark response of 10 % (BMDL10) of 16 mg/kg b.w. reported for changes in thyroid hormones as the critical reference point. Due to the limitations and uncertainties in the database, the CONTAM Panel concluded that it was inappropriate to use this BMDL to establish a health based guidance value, and therefore used a margin of exposure (MOE) approach for the health risk assessment of TBBPA. In view of the large MOEs, the CONTAM Panel concluded that current dietary exposure to TBBPA in the European Union does not raise a health concern. Also exposure of infants via human milk does not raise a health concern. Additional exposure, particularly of young children, to TBBPA from house dust is unlikely to raise a health concern.

Place, publisher, year, edition, pages
2011. Vol. 9, no 12, 2477- p.
Keyword [en]
Tetrabromobisphenol A, TBBPA, TBBPA derivatives, occurrence, food, toxicology, human exposure, risk assessment
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Other Chemistry Topics
URN: urn:nbn:se:su:diva-67973DOI: 10.2903/j.efsa.2011.2477OAI: diva2:471421
On request from: European Commission. Affiliation: European Food Safety Authority (EFSA), Parma, Italy. Panel members: Jan Alexander et al. Working group: Åke Bergman et al.Available from: 2012-01-02 Created: 2012-01-02 Last updated: 2012-01-19Bibliographically approved

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