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Sample treatment based on extraction techniques in biological matrices
Stockholm University, Faculty of Science, Department of Analytical Chemistry.
2011 (English)In: Bioanalysis, ISSN 1757-6180, Vol. 3, no 17, 2003-2018 p.Article, review/survey (Refereed) Published
Abstract [en]

The importance of sample preparation methods as the first stage in bioanalysis is described. In this article, the sample preparation concept and strategies will be discussed, along with the requirements for good sample preparation. The most widely used sample preparation methods in the pharmaceutical industry are presented; for example, the need for same-day rotation of results from large numbers of biological samples in pharmaceutical industry makes high throughput bioanalysis more essential. In this article, high-throughput sample preparation techniques are presented; examples are given of the extraction and concentration of analytes from biological matrices, including protein precipitation, solid-phase extraction, liquid-liquid extraction and microextraction-related techniques. Finally, the potential role of selective extraction methods, including molecular imprinted phases, is considered.

Place, publisher, year, edition, pages
2011. Vol. 3, no 17, 2003-2018 p.
National Category
Natural Sciences
URN: urn:nbn:se:su:diva-67263DOI: 10.4155/BIO.11.201ISI: 000295210300017OAI: diva2:471448
authorCount :2Available from: 2012-01-02 Created: 2011-12-27 Last updated: 2012-01-02Bibliographically approved

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Abdel-Rehim, Mohamed
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