Although the Suchey-Brooks (SB) system is currently the most widely used method for age-at-death estimation from the pubic bone, the system continues to evolve through stepwise improvements. Since the system was developed from a pubic bone sample derived mainly from North Americans, it is unclear how well it performs on populations from other continents. During the last decade, studies of the SB system on pubic bone samples from local populations in Europe and Asia have indicated regional differences in the relationship between age and pubic bone development. However, these studies have for the most part followed different research protocols, which make comparisons between their results less meaningful. It would be most useful if future regional analysis of the SB system were done in a rigorous and uniform fashion, following standard procedures. In this paper, sampling and statistical considerations are outlined that hopefully will help to standardize research on the SB system.