Change search
ReferencesLink to record
Permanent link

Direct link
Circadian rhythms in the morphology of neurons in Drosophila
Stockholm University, Faculty of Science, Department of Zoology.
Stockholm University, Faculty of Science, Department of Zoology.
2011 (English)In: Cell and Tissue Research, ISSN 0302-766X, E-ISSN 1432-0878, Vol. 344, no 3, 381-389 p.Article, review/survey (Refereed) Published
Abstract [en]

Neurons have an enormous capacity to adapt to changing conditions through the regulation of gene expression, morphology, and physiology. In the fruit fly Drosophila melanogaster, this plasticity includes recurrent changes taking place within intervals of a few hours during the day. The rhythmic alterations in the morphology of neurons described so far include changes in axonal diameter, branching complexity, synapse numbers, and the number of synaptic vesicles. The cycles of these changes have larger amplitude when the fly is exposed to light, but they persist in constant darkness and require the expression of the clock genes period and timeless, leading to the concept of circadian plasticity. The molecular mechanisms driving these cycles appear to require the expression of these genes either inside the neurons themselves or in other peripheral pacemaker cells. Loss-of-function mutations in period and timeless not only abolish the morphological rhythms, but also often cause abnormal axonal branching suggesting that circadian plasticity is relevant for the maintenance of normal morphology. Research into whether (1) circadian plasticity is a common feature of neurons in all animals and (2) our own neurons change shape between day and night will be of interest.

Place, publisher, year, edition, pages
2011. Vol. 344, no 3, 381-389 p.
Keyword [en]
Circadian rhythms, Neuronal plasticity, Neuron, Period, Timeless, Drosophila melanogaster (Insecta)
National Category
URN: urn:nbn:se:su:diva-67842DOI: 10.1007/s00441-011-1174-xISI: 000291039400002OAI: diva2:471705
authorCount :2Available from: 2012-01-02 Created: 2012-01-02 Last updated: 2012-01-02Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Mehnert, Kerstin I.Cantera, Rafael
By organisation
Department of Zoology
In the same journal
Cell and Tissue Research

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 77 hits
ReferencesLink to record
Permanent link

Direct link