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Expansion and Activation Kinetics of Immune Cells during Early Phase of GVHD in Mouse Model Based on Chemotherapy Conditioning
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2010 (English)In: Clinical & Developmental Immunology, ISSN 1740-2522, E-ISSN 1740-2530, 142943- p.Article in journal (Refereed) Published
Abstract [en]

In the present paper, we have investigated early pathophysiological events in graft-versus-host disease (GVHD), a major complication to hematopoietic stem cell transplantation (HSCT). BLLB/c female mice conditioned with busulfan/cyclophosphamide (Bu-Cy) were transplanted with allogeneic male C57BL/6. Control group consisted of syngeneic transplanted Balb/c mice. In allogeneic settings, significant expansion and maturation of donor dendritic cells (DCs) were observed at day +3, while donor T-cells CD8+ were increased at day +5 (230%) compared to syngeneic HSCT. Highest levels of inflammatory cytokines IL-2, IFN-gamma, and TNF-alfa at day +5 matched T-cell activation. Concomitantly naive T-cells gain effecr-memory phenotype and migrated from spleen to peripheral lymphoid organs. Thus, in the very early phase of GHVD following Bu-Cy conditioning donor, DCs play an important role in the activation of donor T cells. Subsequently, donor naive T-cells gain effector-memory phenotype and initiate GVHD.

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2010. 142943- p.
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Natural Sciences
URN: urn:nbn:se:su:diva-68202DOI: 10.1155/2010/142943ISI: 000286232400001OAI: diva2:472053
authorCount :9Available from: 2012-01-03 Created: 2012-01-03 Last updated: 2012-01-03Bibliographically approved

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Abedi-Valugerdi, Manuchehr
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Department of Biochemistry and Biophysics
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