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Plasmodium falciparum GPI toxin: A common foe for man and mosquito
Stockholm University, Faculty of Science, Department of Genetics, Microbiology and Toxicology.
2010 (English)In: Acta Tropica, ISSN 0001-706X, E-ISSN 1873-6254, Vol. 114, no 3, 162-165 p.Article in journal (Refereed) Published
Abstract [en]

The glycosylphosphatidylinositol (GPI) anchor of the malaria parasite, Plasmodium falciparum, which can be regarded as an endotoxin, plays a role in the induced pathology associated with severe malaria in humans. However, it is unclear whether the main mosquito vector, Anopheles gambiae, can specifically recognize, and respond to GPI from the malaria parasite. Recent data suggests that the malaria vector does mount a specific response against malaria GPI. In addition, following the strong immune response, mosquito fecundity is severely affected, resulting in a significant reduction in viable eggs produced. In this mini-review we look at the increased interest in understanding the way that malaria antigens are recognized in the mosquito, and how this relates to a better understanding of the interactions between the malaria parasite and both human and vector.

Place, publisher, year, edition, pages
2010. Vol. 114, no 3, 162-165 p.
Keyword [en]
Plasmodium falciparum, Anopheles gambiae, GPI
National Category
Natural Sciences
Identifiers
URN: urn:nbn:se:su:diva-68182DOI: 10.1016/j.actatropica.2009.06.003ISI: 000277099800007PubMedID: 19539593OAI: oai:DiVA.org:su-68182DiVA: diva2:472180
Note
authorCount :2Available from: 2012-01-03 Created: 2012-01-03 Last updated: 2017-12-08Bibliographically approved

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