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Spleen rates in children: an old and new surveillance tool for malaria elimination initiatives in island settings
Stockholm University, Faculty of Science, The Wenner-Gren Institute , Immunology.
2011 (English)In: Transactions of the Royal Society of Tropical Medicine and Hygiene, ISSN 0035-9203, E-ISSN 1878-3503, Vol. 105, no 4, 226-231 p.Article in journal (Refereed) Published
Abstract [en]

Spleen rates (SR) have been traditionally used to estimate the burden of malaria transmission. Results are presented from 51 surveys, which measured SR and parasite rates (PR) in 29 962 individuals in the archipelago of Vanuatu. Indices for spleen size computed with multivariate statistical tools outperformed the WHO average spleen index and showed that spleen sizes in a population can track shifts in malaria transmission. In general, a positive linear relationship between Plasmodium spp. PR and SR was found for the archipelago. In the context of malaria elimination and for the specific setting of this study we found that spleen examination is a useful tool in post-malaria elimination surveillance. Finally, results highlight the value of measuring spleen sizes to rapidly assess the impact of intervention packages aimed at malaria elimination or control.

Place, publisher, year, edition, pages
2011. Vol. 105, no 4, 226-231 p.
Keyword [en]
Vanuatu, Malaria elimination, Spleen indices, Linear mixed effects models, Bednets
National Category
URN: urn:nbn:se:su:diva-68827DOI: 10.1016/j.trstmh.2011.01.001ISI: 000289334200008OAI: diva2:474083
authorCount :4Available from: 2012-01-09 Created: 2012-01-07 Last updated: 2012-01-09Bibliographically approved

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