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Hunting for Protein Markers of Hypoxia by Combining Plasma Membrane Enrichment with a New Approach to Membrane Protein Analysis
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
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2011 (English)In: Journal of Proteome Research, ISSN 1535-3893, E-ISSN 1535-3907, Vol. 10, no 4, 1645-1656 p.Article in journal (Refereed) Published
Abstract [en]

Nontransient hypoxia is strongly associated with malignant lesions, resulting in aggressive behavior and resistance to treatment. We present an analysis of mRNA and protein expression changes in neuroblastoma cell lines occurring upon the transition from normoxia to hypoxia. The correlation between mRNA and protein level changes was poor, although some known hypoxia-driven genes and proteins correlated well. We present previously undescribed membrane proteins expressed under hypoxic conditions that are candidates for evaluation as biomarkers.

Place, publisher, year, edition, pages
2011. Vol. 10, no 4, 1645-1656 p.
Keyword [en]
isotopic labeling, HPLC-MS, 2D-PAGE, plasma membrane, protein expression, mRNA expression, correlation, hypoxia, normoxia, neuroblastoma
National Category
Biological Sciences
URN: urn:nbn:se:su:diva-69106DOI: 10.1021/pr100982jISI: 000288924000019OAI: diva2:474920
authorCount :13Available from: 2012-01-10 Created: 2012-01-10 Last updated: 2012-01-10Bibliographically approved

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Bendz, Maria
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ReferencesLink to record
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