Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Hunting for Protein Markers of Hypoxia by Combining Plasma Membrane Enrichment with a New Approach to Membrane Protein Analysis
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
Show others and affiliations
2011 (English)In: Journal of Proteome Research, ISSN 1535-3893, E-ISSN 1535-3907, Vol. 10, no 4, 1645-1656 p.Article in journal (Refereed) Published
Abstract [en]

Nontransient hypoxia is strongly associated with malignant lesions, resulting in aggressive behavior and resistance to treatment. We present an analysis of mRNA and protein expression changes in neuroblastoma cell lines occurring upon the transition from normoxia to hypoxia. The correlation between mRNA and protein level changes was poor, although some known hypoxia-driven genes and proteins correlated well. We present previously undescribed membrane proteins expressed under hypoxic conditions that are candidates for evaluation as biomarkers.

Place, publisher, year, edition, pages
2011. Vol. 10, no 4, 1645-1656 p.
Keyword [en]
isotopic labeling, HPLC-MS, 2D-PAGE, plasma membrane, protein expression, mRNA expression, correlation, hypoxia, normoxia, neuroblastoma
National Category
Biological Sciences
Identifiers
URN: urn:nbn:se:su:diva-69106DOI: 10.1021/pr100982jISI: 000288924000019OAI: oai:DiVA.org:su-69106DiVA: diva2:474920
Note
authorCount :13Available from: 2012-01-10 Created: 2012-01-10 Last updated: 2017-12-08Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Bendz, Maria
By organisation
Department of Biochemistry and Biophysics
In the same journal
Journal of Proteome Research
Biological Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 30 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf