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Noise benefit in prepulse inhibition of the acoustic startle reflex
Stockholm University, Faculty of Humanities, Department of Linguistics.
2011 (English)In: Psychopharmacology, ISSN 0033-3158, E-ISSN 1432-2072, Vol. 214, no 3, 675-685 p.Article in journal (Refereed) Published
Abstract [en]

Under some conditions, external sensory noise enhances cognitive functions, a phenomenon possibly involving stochastic resonance and/or enhanced central dopamine transmission. Prepulse inhibition (PPI) of the startle reflex is a robust measure of sensorimotor gating and can be modulated by activity in the cortex and basal ganglia, including the central dopamine pathways. Previous empirical studies suggest a differential effect of acoustic noise in normal children and children with attention-deficit hyperactivity disorder (ADHD). This study investigated the effect of acoustic noise on PPI and if dopamine transmission interacts with acoustic noise effects in a rat ADHD model. The effect of background acoustic noise on acoustic startle response and PPI were measured with a constant prepulse to background noise ratio of 9 dB(A). Spontaneously hypertensive (SH) rats were used as the ADHD model and compared with Wistar and Sprague-Dawley rats. Microdialysis, methylphenidate treatment and 6-OHDA lesions were used to investigate interaction with dopamine transmission. Background noise facilitated PPI differently in SH rats and controls. The prefrontal cortex in SH rats had low basal dopamine concentrations, a high DOPAC/dopamine ratio and blunted dopamine release during PPI testing. Methylphenidate had small, but strain-specific, effects on startle and PPI. Bilateral 6-hydroxydopamine lesions did not alter startle or PPI. Prefrontal dopamine transmission is altered in SH rats during the sensorimotor gating task of PPI of the acoustic startle, indicating increased dopamine reuptake in this ADHD rat model. We propose that noise benefit could be explored as a non-pharmacological alternative for treating neuropsychiatric disorders.

Place, publisher, year, edition, pages
2011. Vol. 214, no 3, 675-685 p.
Keyword [en]
Spontaneously hypertensive rat, Attention-deficit hyperactivity disorder, Acoustic startle, Prepulse inhibition, White noise, Stochastic resonance, Dopamine, Methylphenidate, Microdialysis, Prefrontal cortex
National Category
General Language Studies and Linguistics
Identifiers
URN: urn:nbn:se:su:diva-69093DOI: 10.1007/s00213-010-2074-6ISI: 000288253500009OAI: oai:DiVA.org:su-69093DiVA: diva2:475094
Note
authorCount :4Available from: 2012-01-10 Created: 2012-01-10 Last updated: 2017-12-08Bibliographically approved

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