Persistent organic pollutants have dose and CAG repeat length dependent effects on androgen receptor activity in vitro
2011 (English)In: Reproductive Toxicology, ISSN 0890-6238, E-ISSN 1873-1708, Vol. 32, 293-297 p.Article in journal (Refereed) Published
Recently, the effect of exposure to persistent organic pollutants (POPS) on sperm concentration was only seen in men with a short androgen receptor (AR) gene CAG repeat. In order to investigate whether these effects could be observed also in vitro, we tested the impact of 2,2’,4,4’,5,5’-hexachlorobiphenyl (CB-153) and 1,1-bis-(4-chlorophenyl)-2,2-dichloroethene (4,4’-DDE) on 5 alpha-dihydrotestosterone activated ARs containing 16,22 and 28 CAG repeats, respectively. Single exposure to 4,4’-DDE had the most pronounced effect on the AR activity containing 16 CAG repeats, whereas 28 CAG was the most sensitive variant when a mixture of the two compounds was added. Thus, our in vitro results have confirmed the in vivo data indicating a CAG repeat length dependent effect of endocrine disrupters on the AR activity.
Place, publisher, year, edition, pages
2011. Vol. 32, 293-297 p.
Pharmacology and Toxicology Biological Sciences
IdentifiersURN: urn:nbn:se:su:diva-69372DOI: 10.1016/j.reprotox.2011.06.075ISI: 000296935100006OAI: oai:DiVA.org:su-69372DiVA: diva2:476430
authorCount :62012-01-122012-01-122012-01-25Bibliographically approved