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Persistent organic pollutants have dose and CAG repeat length dependent effects on androgen receptor activity in vitro
Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK), Environmental Chemistry.
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2011 (English)In: Reproductive Toxicology, ISSN 0890-6238, E-ISSN 1873-1708, Vol. 32, 293-297 p.Article in journal (Refereed) Published
Abstract [en]

Recently, the effect of exposure to persistent organic pollutants (POPS) on sperm concentration was only seen in men with a short androgen receptor (AR) gene CAG repeat. In order to investigate whether these effects could be observed also in vitro, we tested the impact of 2,2’,4,4’,5,5’-hexachlorobiphenyl (CB-153) and 1,1-bis-(4-chlorophenyl)-2,2-dichloroethene (4,4’-DDE) on 5 alpha-dihydrotestosterone activated ARs containing 16,22 and 28 CAG repeats, respectively. Single exposure to 4,4’-DDE had the most pronounced effect on the AR activity containing 16 CAG repeats, whereas 28 CAG was the most sensitive variant when a mixture of the two compounds was added. Thus, our in vitro results have confirmed the in vivo data indicating a CAG repeat length dependent effect of endocrine disrupters on the AR activity.

Place, publisher, year, edition, pages
2011. Vol. 32, 293-297 p.
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Pharmacology and Toxicology Biological Sciences
URN: urn:nbn:se:su:diva-69372DOI: 10.1016/j.reprotox.2011.06.075ISI: 000296935100006OAI: diva2:476430
authorCount :6Available from: 2012-01-12 Created: 2012-01-12 Last updated: 2012-01-25Bibliographically approved

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Bergman, Åke
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