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An Introduction to Membrane Proteins
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.ORCID iD: 0000-0002-7115-9751
2011 (English)In: Journal of Proteome Research, ISSN 1535-3893, E-ISSN 1535-3907, Vol. 10, no 8, 3324-3331 p.Article in journal (Refereed) Published
Abstract [en]

alpha-Helical membrane proteins are important for many biological functions. Due to physicochemical constraints, the structures of membrane proteins differ from the structure of soluble proteins. Historically, membrane protein structures were assumed to be more or less two-dimensional, consisting of long, straight, membrane-spanning parallel helices packed against each other. However, during the past decade, a number of the new membrane protein structures cast doubt on this notion. Today, it is evident that the structures of many membrane proteins are equally complex as for many soluble proteins. Here, we review this development and discuss the consequences for our understanding of membrane protein biogenesis, folding, evolution, and bioinformatics.

Place, publisher, year, edition, pages
2011. Vol. 10, no 8, 3324-3331 p.
Keyword [en]
membrane proteins, bioinformatics, protein structure, protein evolution, translocon insertion, protein biogenesis
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:su:diva-69241DOI: 10.1021/pr200145aISI: 000293487900003OAI: oai:DiVA.org:su-69241DiVA: diva2:476881
Funder
Swedish Research Council, VR-NT 2009-5072; VR-M 2010-3555EU, FP7, Seventh Framework Programme, 512092; 201924Swedish Foundation for Strategic Research
Note

authorCount :3

Available from: 2012-01-12 Created: 2012-01-11 Last updated: 2017-12-08Bibliographically approved

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