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Coagulation Systems of Invertebrates and Vertebrates and Their Roles in Innate Immunity: The Same Side of Two Coins?
Stockholm University, Faculty of Science, Department of Molecular Biology and Functional Genomics.
2011 (English)In: Journal of Innate Immunity, ISSN 1662-811X, Vol. 3, no 1, 34-40 p.Article, review/survey (Refereed) Published
Abstract [en]

Bacterial infections represent a serious health care problem, and all multicellular organisms have developed defense mechanisms to eliminate pathogens that enter the host via different paths including wounds. Many invertebrates have an open circulatory system, and effective coagulation systems are in place to ensure fast and efficient closure of wounds. It was proposed early on that coagulation systems in invertebrates play a major role not only in sealing wounds but also in preventing systemic infections. More recent evidence suggests that vertebrates, too, rely on clotting as an immune effector mechanism. Here we discuss the evolution of clotting systems against the background of their versatile function in innate immunity. Copyright (C) 2010 S. Karger AG, Basel

Place, publisher, year, edition, pages
2011. Vol. 3, no 1, 34-40 p.
Keyword [en]
Coagulation, Host defense, Immune response, Invertebrates, Vertebrates
National Category
Natural Sciences
URN: urn:nbn:se:su:diva-69711DOI: 10.1159/000321641ISI: 000285568700006OAI: diva2:478003
authorCount :4Available from: 2012-01-15 Created: 2012-01-15 Last updated: 2012-02-16Bibliographically approved

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Theopold, Ulrich
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Department of Molecular Biology and Functional Genomics
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