Regional Differences in Effects of APOE epsilon 4 on Cognitive Impairment in Non-Demented Subjects
2011 (English)In: Dementia and Geriatric Cognitive Disorders, ISSN 1420-8008, E-ISSN 1421-9824, Vol. 32, no 2, 135-142 p.Article in journal (Refereed) Published
Background: The APOE epsilon 4 allele is a risk factor for Alzheimer's disease (AD). APOE epsilon 4 is common in non-demented subjects with cognitive impairment. In both healthy people and people with AD, its prevalence has a north-south gradient across Europe. In the present study, we investigated whether the relation between the APOE epsilon 4 allele and cognitive impairment varied across Northern, Middle and Southern Europe. We also investigated whether a north-south gradient existed in subjects with subjective cognitive impairment (SCI), amnestic mild cognitive impairment (MCI) and non-amnestic MCI. Methods: Data from 16 centers across Europe were analyzed. Results: A north-south gradient in APOE epsilon 4 prevalence existed in the total sample (62.7% for APOE epsilon 4 carriers in the northern region, 42.1% in the middle region, and 31.5% in the southern region) and in subjects with SCI and amnestic MCI separately. Only in Middle Europe was the APOE epsilon 4 allele significantly associated with poor performance on tests of delayed recall and learning, as well as with the amnestic subtype of MCI. Conclusion: The APOE epsilon 4 allele frequencies in subjects with SCI and amnestic MCI have a north-south gradient. The relation between the APOE epsilon 4 allele and cognition is region dependent.
Place, publisher, year, edition, pages
2011. Vol. 32, no 2, 135-142 p.
Alzheimer's disease, APOE epsilon 4 allele, Europe, Gradient
Medical and Health Sciences
Research subject Psychology
IdentifiersURN: urn:nbn:se:su:diva-69920DOI: 10.1159/000330492ISI: 000295875400008OAI: oai:DiVA.org:su-69920DiVA: diva2:479097
authorCount :242012-01-172012-01-152012-02-02Bibliographically approved