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Cell-penetrating peptides-based strategies for the delivery of splice redirecting antisense oligonucleotides
Stockholm University, Faculty of Science, Department of Neurochemistry.
Université Montpellier, Motpellier, France.
Université Montpellier, Motpellier, France.
University of Tartu, Institute of Technology, Tartu, Estonia.
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2011 (English)In: Therapeutic Oligonucleotides: Methods and Protocols / [ed] John Goodchild, New York: Humana Press, 2011, 75-89 p.Chapter in book (Other academic)
Abstract [en]

Progress in our understanding of the molecular pathogenesis of human malignancies has provided therapeutic targets amenable to oligonucleotide (ON)-based strategies. Antisense ON-mediated splicing regulation in particular offers promising prospects since the majority of human genes undergo alternative splicing and since splicing defects have been found in many diseases. However, their implementation has been hampered so far by the poor bioavailability of nucleic acids-based drugs. Cell-penetrating peptides (CPPs) now appear as promising non-viral delivery vector for non-permeant biomolecules. We describe here new CPPs allowing the delivery of splice redirecting steric-block ON using either chemical conjugation or non-covalent complexation. We also describe a convenient and robust splice redirecting assay which allows the quantitative assessment of ON nuclear delivery.

Place, publisher, year, edition, pages
New York: Humana Press, 2011. 75-89 p.
Series
Methods in Molecular Biology, ISSN 1064-3745 ; 764
Keyword [en]
cpp, cell-penetrating peptides, transfection
National Category
Cell and Molecular Biology Chemical Sciences Other Chemistry Topics Biochemistry and Molecular Biology
Research subject
Neurochemistry with Molecular Neurobiology
Identifiers
URN: urn:nbn:se:su:diva-70620DOI: 10.1007/978-1-61779-188-8_5OAI: oai:DiVA.org:su-70620DiVA: diva2:482181
Available from: 2012-01-23 Created: 2012-01-23 Last updated: 2015-04-21Bibliographically approved

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Langel, Ülo
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