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Mechanisms of Cellular Uptake of Cell-Penetrating Peptides
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
Stockholm University, Faculty of Science, Department of Neurochemistry.ORCID iD: 0000-0001-7746-8574
Stockholm University, Faculty of Science, Department of Neurochemistry.ORCID iD: 0000-0001-6107-0844
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2011 (English)In: Journal of Biophysics, ISSN 1687-8000, E-ISSN 1687-8019, 414729Article, review/survey (Refereed) Published
Abstract [en]

Recently, much attention has been given to the problem of drug delivery through the cell-membrane in order to treat and manage several diseases. The discovery of cell penetrating peptides (CPPs) represents a major breakthrough for the transport of large-cargo molecules that may be useful in clinical applications. CPPs are rich in basic amino acids such as arginine and lysine and are able to translocate over membranes and gain access to the cell interior. They can deliver large-cargo molecules, such as oligonucleotides, into cells. Endocytosis and direct penetration have been suggested as the two major uptake mechanisms, a subject still under debate. Unresolved questions include the detailed molecular uptake mechanism(s), reasons for cell toxicity, and the delivery efficiency of CPPs for different cargoes. Here, we give a review focused on uptake mechanisms used by CPPs for membrane translocation and certain experimental factors that affect the mechanism(s).

Place, publisher, year, edition, pages
2011. 414729
National Category
Chemical Sciences Biochemistry and Molecular Biology
Research subject
Biochemistry; Biophysics; Neurochemistry with Molecular Neurobiology
URN: urn:nbn:se:su:diva-70695DOI: 10.1155/2011/414729OAI: diva2:482237
Swedish Research Council
Available from: 2012-01-23 Created: 2012-01-23 Last updated: 2015-09-04Bibliographically approved

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Madani, FatemehLindberg, StaffanLangel, ÜloGräslund, Astrid
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Department of Biochemistry and BiophysicsDepartment of Neurochemistry
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