Nonequilibrium phase transitions in biomolecular signal transduction
2011 (English)In: Physical Review E. Statistical, Nonlinear, and Soft Matter Physics, ISSN 1539-3755, Vol. 84, no 5, 051917- p.Article in journal (Refereed) Published
We study a mechanism for reliable switching in biomolecular signal-transduction cascades. Steady bistable states are created by system-size cooperative effects in populations of proteins, in spite of the fact that the phosphorylation-state transitions of any molecule, by means of which the switch is implemented, are highly stochastic. The emergence of switching is a nonequilibrium phase transition in an energetically driven, dissipative system described by a master equation. We use operator and functional integral methods from reaction-diffusion theory to solve for the phase structure, noise spectrum, and escape trajectories and first-passage times of a class of minimal models of switches, showing how all critical properties for switch behavior can be computed within a unified framework.
Place, publisher, year, edition, pages
2011. Vol. 84, no 5, 051917- p.
IdentifiersURN: urn:nbn:se:su:diva-70657DOI: 10.1103/PhysRevE.84.051917ISI: 000297468200003OAI: oai:DiVA.org:su-70657DiVA: diva2:482679
authorCount :42012-01-242012-01-232012-01-24Bibliographically approved