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Prevalence of colonic neoplasia and advanced lesions in the normal population: a prospective population-based colonoscopy study.
Stockholm University, Faculty of Social Sciences, Stress Research Institute. (Enheten för biologi och behandlingsforskning)
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2012 (English)In: Scandinavian journal of gastroenterology, ISSN 1502-7708, Vol. 47, no 2, 184-90 p.Article in journal (Refereed) Published
Abstract [en]

Abstract Objective. There are few prospective studies of the prevalence of colonic neoplasia in the normal population. In order to properly evaluate screening-protocols for colorectal cancer in risk groups (e.g., older subjects or those with a family history), it is essential to know the prevalence of adenomas and cancer in the normal population. Methods. A prospective population-based colonoscopy study on 745 individuals born in Sweden aged 19-70 years was conducted (mean age 51.1 years). All polyps seen were retrieved and examined. Results. Out of the 745 individuals 27% had polyps, regardless of kind. Adenomas were found in 10% of the individuals and finding of adenomas was positively correlated to higher age. Men had adenomas in 15% and women in 6% of the cases. Women had a right-sided dominance of adenomas. Hyperplastic polyps were seen in 21% of the individuals. The presence of hyperplastic polyps was significantly positively correlated to the presence of adenomas. Advanced adenomas were seen in 2.8% of the study participants, but no cancers were detected. Conclusion. One in 10 healthy subjects had an adenoma but advanced adenomas were uncommon. Men and women have a different adenoma prevalence and localization. The results provide baseline European data for evaluating colonoscopy screening-protocols for colorectal cancer risk groups, and the findings may have implications for colon cancer screening in the normal, otherwise-healthy population.

Place, publisher, year, edition, pages
2012. Vol. 47, no 2, 184-90 p.
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Medical and Health Sciences
URN: urn:nbn:se:su:diva-70929DOI: 10.3109/00365521.2011.647062ISI: 000299126200008PubMedID: 22229966Local ID: P2901OAI: diva2:483076
Available from: 2012-01-24 Created: 2012-01-24 Last updated: 2012-06-07Bibliographically approved

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Nixon Andreasson, Anna
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Stress Research Institute
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